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Prostaglandin E2 regulates pancreatic stellate cell activity via the EP4 receptor

This dual activation leads to improved insulin secretion in response to elevated blood glucose levels, while also reducing glucagon levels, thereby optimizing blood sugar control

Photo: Getty Images June 2, 2026 Results of an American College of Radiology-managed retrospective study involving 110,000 women presented at the 2026 ASCO Annual Meeting, shows that those who took GLP-1 medications were up to 35% less likely to develop breast cancer than those who did not take GLP-1 drugs

Mallika Marshall

Conversely, Hantson and coworkers [83] recently reported the case of a 47-year-old epileptic man in whom parenteral VPA therapy was associated with a severe hyperammonaemic encephalopathy (peak ammonia concentration 411 mol/l) without any biological signs of hepatotoxicity